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Preparation of triazolopyridazinyl and imidazopyridazinyl pyrazoles as TRAF 6 inhibitors. In vivo imaging of MMP-13 activity using a specific polymer-FRET peptide conjugate detects early osteoarthritis and inhibitor efficacy. Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.

Selective glucagon receptor agonists comprising a chelating moiety for imaging purposes. Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein. First-in-class PET tracer for the glucagon receptor. Long-term cold adaptation does not require FGF21 or UCP1. Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices.

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End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899. In vivo performance and biocompatibility of a subcutaneous implant for real-time glucose-responsive insulin delivery.

In vivo imaging of drug action. In vivo imaging of mouse tumors by a lipidated cathepsin S substrate. FRET-based and other fluorescent proteinase probes. Rho kinase inhibition mitigates sunitinib-induced rise in arterial pressure and renal vascular resistance but not increased renal sodium reabsorption. Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease.

The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. Pharmacological characterization of SAR407899, a novel rho-kinase chiropractor. Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as rho kinase inhibitors. Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and rats.

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