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In addition, more and more studies should amitriptyline focus on the biocompatibility improvement and evaluate the amitriptyline efficiency against oral diseases in animal studies and clinical trials. YaW and WX wrote the manuscript. XR portal johnson YuW participated and helped with the final revision of the manuscript.

LW and BD designed and critically revised the review manuscript. All the authors amitriptyline and approved the final version of the manuscript prior to submission. This study was supported by the Natural Science Foundation of China NSFC 81400487 amitriptyline China Postdoctoral Science Foundation 2015M581405 and 2017T100213 (LW); General program of Natural Science Foundation of Amitriptyline Province 20200201356JC (LW) and 20200201317JC (CL); and seed grant from Jilin University School of Dentistry (LW).

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