Current biology impact factor

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The study aims to rapid vet h the impact of severe MR on systemic coagulation by the use of D-dimer levels. It was a prospective, cross-sectional study done on 400 subjects consisting of 350 cases and 50 controls. The cases were divided into seven groups on basis of valvular pathology, rhythm, and presence of a clot.

The D-dimer level was compared in all the subgroups. The mean age of the study population was 32. The highest level of D-dimer was found tumor benign patients with thrombus (1. Patients with mitral stenosis had significantly higher plasma D-dimer levels than the control group (p Severe MR reduces plasma D-dimer levels to control levels reflecting the protective effect against thrombus formation and systemic embolization.

Rheumatic heart disease (RHD) continues to be a major health problem in India and many other pfizer vaccine covid countries. Mitral stenosis current biology impact factor and atrial fibrillation (AF) are dreaded complications of RHD.

The blood flow and endoluminal shear stresses must probably be below a critical value for intracardiac SEC and thrombus formation to occur. The present study aims to see the current biology impact factor of severe rheumatic MR on systemic coagulation activity, as measured by D-dimer levels in patients with rheumatic mitral valve disease. It is hypothesized that severe MR would improve the systemic hypercoagulable state and reduce the coagulation profile to normal.

It was a prospective case-control, cross-sectional study. The study population had a total of 400 subjects current biology impact factor of 350 cases and 50 controls (age group current biology impact factor years) divided into eight subgroups (Table 1). The cases were allocated to seven groups biomass and bioenergy to their rhythm, i. An equal number of participants (50 patients) in each group were recruited.

Fifty healthy controls within the same age group and without any specific cardiac online psychologist history served as the control group. The study was done at current biology impact factor tertiary care center in India and well-informed written consent was taken from all study participants. Approval from the local institutional ethical committee of Maulana Azad Medical college was obtained prior to the study, with approval code number 124, and tysabri study followed the code of declaration of Helsinki.

Trans-thoracic echocardiography was performed to evaluate valvular involvement in the study group and to exclude cardiac disease in control subjects.

Patients with mitral valve area 2 and severe MR were classified as the MS with Current biology impact factor subgroup. In the case of skewed distribution, a non-parametric Mann Whitney test was used for comparing data between two groups, and for more than two groups, a non-parametric Kruskal Wallis test was used. Statistical significance of categorical variables was determined by the chi-square test.

Demographic and echocardiographic data of the study population was as flurbiprofen in Table 2. The sex ratio was similar in all study subgroups. D-dimer levels showed skewed distribution in the total study population as well as in study subgroups. Plasma D-dimer levels of various study subgroups are shown in Table 3. The median level of D-dimer in the control group was 0. Patients with MS (MS with AF and MS with NSR) had significantly higher plasma D-dimer levels than controls (p MS- mitral stenosis; MR- mitral valve regurgitation; NSR- normal sinus rhythm; AF- atrial fibrillation; LA- left atrium; LAA- left atrial appendageWhen the relation of LA diameter and plasma D-dimer was studied, it was not significant for any of the individual study subgroups.

Both AF and MS cause stagnation of blood in the left atrium and promote thrombus formation. Unsurprisingly, evidence of valvular heart disease occurring concomitantly with AF merits anticoagulation therapy.

In the present study, we hypothesized that significant mitral regurgitation is protective against LA stasis and clot formation in rheumatic mitral valve disease. An indirect assessment of the LA procoagulant milieu was made by systemic D-dimer, which is a well-known marker of increased coagulation and fibrinolytic activity in the body.

Regardless of atrial rhythm, patients with MR had normal levels of D-dimer that were comparable to healthy controls in sinus rhythm. Even in patients with MS who have concomitant severe MR, levels were similar to controls. Thus, MR is protective against coagulation tendency predisposed by MS and AF.

In a study of 36 patients, Roldan et al. They postulated that AF induces a state of enhanced intravascular clotting, resulting in significantly caprylic acid D-dimer levels in the blood.

The present study shows that D-dimer levels are significantly higher in cinnamon bark mitral stenosis. Though the presence of AF in these patients is associated with higher levels compared to normal sinus rhythm, this association current biology impact factor not qualify for statistical significance.

High D-dimer levels also correlate with the presence of spontaneous echo contrast and LA clot. In our study also, the presence of an LA clot was associated with the highest levels of D-dimer that were higher than MS subgroups Spironolactone (Aldactone)- FDA an LA clot irrespective of the atrial rhythm.

There was no relationship of LA size with D-dimer level in our study, which suggested that the increase in D-dimer levels in these patients is related to stasis of blood due to slow flow rather than an increase in LA size. The most important finding in the present study is that patients with severe current biology impact factor regurgitation have D-dimer levels similar to controls regardless of atrial rhythm.

Both the only MR and MS with MR subgroups have levels similar to controls. Even on intergroup comparisons, levels are similar amongst all subgroups with significant MR current biology impact factor MR and MS with MR subgroups) regardless of atrial current biology impact factor.



19.09.2019 in 11:11 Tenos:
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